How It Works ?
The traditional formulation of insoluble or instable compounds uses a combination of surfactants, organic cosolvents or pH modification. These
formulations are poorly tolerated and cause often irritation and
adverse reactions. Sometimes, the formulation needs complicated and expensive solutions by exemple with nanoparticles or liposomes.
We have validated this technology with many insoluble products : progesterone, nimesulide, fenofibrate, piroxicam, albendazole, itraconazole, spironolactone, aciclovir, cyclosporine...
PolyCyc for solubilization :
Many kind of insoluble compounds can be effectively associated with PolyCyc®. Aqueous apparent solubility has increased by a factor of 10 to 10,000, depending on the compound. The effectiveness validation of this solution requires only a few and quickly laboratory tests following the Higushi method.
PolyCyc for stabilization :
Inclusion inside PolyCyc provides a more effective protected environment than with traditional cyclodextrin. Insoluble compounds are not only included inside the lipophilic cavity of the cyclodextrins of PolyCyc but inside the polymer with many binding interactions. Inclusion inside Polycyc increases both solubility and stability. Polycyc can also stabilize soluble compounds by the creation of hydrogen binding between cyclodextrins and compounds. Interaction with Polycyc reduces degradation by protecting reactive regions of compounds.
PolyCyc for amorphous solid dispersion :
The developed technology allows the elaboration of Amorphous Solid Dispersion from innovative cyclodextrin polymers. This solid dispersion can modify the poor soluble compounds to an amorphous state to improve strongly their solubility, dissolution, stability and bioavailability. This technology is applicable for the development of new pharmaceutical formulations for various routes of administration in particular for the oral route. The solution has demonstrated that this amorphous state is stable durind a long time.